Creative Biolabs has developed a comprehensive suite of antibody tools targeting key neuroscience proteins, addressing the growing global burden of neurodegenerative diseases, movement disorders, and psychiatric conditions. The nervous system's complexity requires integration of molecular biology, structural biology, and clinical medicine, driving the need for precise research tools that can illuminate molecular mechanisms underlying neurological conditions.
The company's new anti-GRID2 antibody products, including Rabbit Anti-GRID2 Recombinant Antibody and Mouse Anti-GRID2 Recombinant Antibody, target a gene crucial for cerebellar function and synaptic transmission. Research has demonstrated that GRID2 mutations lead to cerebellar ataxia and learning deficits, making this protein a dominant factor in motor coordination. These antibody tools are applicable in multiple research applications including ELISA, flow cytometry, Western blotting, and immunohistochemistry, allowing researchers to study spatial characteristics and dynamic regulation of synaptic proteins with high specificity.
In neurotransmitter research, Creative Biolabs offers the Mouse Anti-Tyrosine Hydroxylase Recombinant Antibody targeting tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis. This enzyme catalyzes the conversion of L-tyrosine to L-DOPA, which subsequently produces dopamine, norepinephrine, and epinephrine. TH serves as an important marker in Parkinson's disease research, where changes in its levels reflect the functional state of dopaminergic neurons, making it critical for both understanding disease mechanisms and developing neuroprotective strategies.
For muscle genetics research, the company provides ACTN3-related products including Mouse Anti-ACTN3 Recombinant Antibody and Rabbit Anti-ACTN3 Recombinant Antibody. The ACTN3 gene encodes α-actinin-3, a critical protein for maintaining structural integrity and explosive power of fast-twitch muscle fibers. These tools support studies in sports genetics, muscle disorders, and personalized training research, with applications spanning immunohistochemistry, Western blotting, immunocytochemistry, and flow cytometry.
A neuroscientist at Creative Biolabs emphasized that GRID2 has emerged as a key point for understanding both cerebellar development and mechanism learning, with the antibody tool sets designed to assist researchers in generating clearer molecular maps within cell and animal model systems. The development of these specialized antibody tools represents a significant advancement for neuroscience research communities investigating synaptic function, neurotransmitter pathways, and muscle genetics.
