Electromagnetic network-targeted field therapy combined with physical therapy significantly reduced overall disability in stroke survivors compared to those receiving sham stimulation with physical therapy, according to preliminary research to be presented at the American Stroke Association’s International Stroke Conference 2026. The analysis of two small clinical trials found that 33.8% of participants receiving ENTF therapy achieved freedom from disability after three months, compared to just 11.9% in the sham treatment group. Researchers examined combined data from 124 stroke survivors who were moderately to severely disabled following ischemic stroke. Participants received either ENTF therapy or sham treatment beginning an average of 14 days after their stroke, with all receiving 40 to 45 sessions over 8 to 12 weeks alongside physical therapy. The therapy targets specific brain networks related to motor movement and cognitive functions that become electrically disorganized after stroke.
These neural networks show electrical disorganization after a stroke. Stimulating these networks with electromagnetic pulse patterns derived from studies in people who have not had a stroke can model and facilitate the reestablishment of normal network organization, said lead study author Jeffrey L. Saver, M.D., FAHA, of UCLA's David Geffen School of Medicine. The therapy showed no serious adverse effects and participants used portable kits allowing treatment to begin in the hospital and continue at home. American Stroke Association volunteer expert Joseph P. Broderick, M.D., FAHA, noted the preliminary nature of the findings while acknowledging the strong demand for new recovery methods post-stroke. This study examines two small trials of electromagnetic network-targeted field therapy for stroke patients. The results are preliminary, highlighting the need for larger trials with balanced participant groups to assess the therapy’s effectiveness, said Broderick, who was not involved in the study.
The research comes as stroke remains a leading cause of long-term disability in the United States, where it is now the fourth leading cause of death according to the American Heart Association’s Heart Disease and Stroke Statistics 2026 Update available at https://www.heart.org. Motor impairment affecting arm and leg movement is the most common complication after stroke, creating significant challenges for survivors returning to daily activities. Study participants had an average modified Rankin Scale score of 3.9 at enrollment, indicating moderate to severe disability. Beyond the significant increase in disability-free outcomes, researchers observed measurable improvements across the full range of disability outcomes in the ENTF group. The analysis combined data from the BQ3 and EMAGINE trials conducted between 2021 and 2025, with findings considered preliminary until published in a peer-reviewed journal.
Researchers emphasize that while the results are promising, the main limitation is the analysis of data from two small pilot studies. A single, larger trial is needed to confirm these findings before the therapy could be widely implemented. The abstract is available in the American Stroke Association International Stroke Conference 2026 Online Program Planner at https://professional.heart.org. Additional information about stroke recovery is available through the American Stroke Association at https://www.stroke.org.
